{"id":808,"date":"2019-01-14T16:10:49","date_gmt":"2019-01-14T16:10:49","guid":{"rendered":"http:\/\/dev.jatstudio.com\/publications"},"modified":"2020-11-18T09:41:04","modified_gmt":"2020-11-18T09:41:04","slug":"publications","status":"publish","type":"page","link":"https:\/\/dev.jatstudio.com\/en\/publications","title":{"rendered":"Publications"},"content":{"rendered":"\t\t
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Publications<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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1. Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy. Redox Biol<\/em>. Apr 2018<\/strong>.\u00a0DOI<\/strong>: 10.1016\/j.redox.2017.10.010.<\/a><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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2. Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach. Pharmacol Rev.<\/em> April 2018<\/b>.\u00a0DOI:\u00a0<\/b>10.1124\/pr.117.014753<\/a><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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3. Transcription factor NFE2L2\/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A. Autophagy<\/em>. Jul\u00a02018<\/strong>. DOI<\/strong>: 10.1080\/15548627.2018.1474992<\/a><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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4. Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy. Redox Biol<\/em>. Sep\u00a02018<\/strong>.\u00a0DOI<\/strong>: 10.1016\/j.redox.2018.07.006<\/a><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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5. Multi-target-directed ligands for Alzheimer\u00b4s disease: discovery of chromone-based monoamine oxidase\/cholinesterase inhibitors. Eur. J. Med. Chem<\/em>. Oct\u00a02018<\/strong>. DOI<\/strong>: 10.1016\/j.ejmech.2018.07.056<\/a><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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6. Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases. Nat Rev Drug Discov<\/em>. Jan\u00a02019<\/strong>.\u00a0DOI<\/strong>: 10.1038\/s41573-018-0008-x<\/a><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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7. New flavonoid \u2013 N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer\u00b4s disease endowed with neurogenic properties. J. Enzyme Inhib. Med. Chem.<\/em> Mar 2019<\/strong>. DOI<\/strong>:\u00a010.1080\/14756366.2019.1581184<\/a><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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8. Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development. Oxid Med Cell Longev<\/em>. Jul 2019<\/strong>. DOI<\/strong>: 10.1155\/2019\/9372182<\/a><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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9. Melatonin-sulforaphane hybrid ITH12674 attenuates glial response in vivo by blocking LPS binding to MD2 and receptor oligomerization. Pharmacological Research<\/em>. Feb 2020<\/strong>. DOI: <\/strong>10.1016\/j.phrs.2019.104597<\/a><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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10. Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties. Eur. J. Med. Chem<\/em>. Mar 2020<\/strong>. DOI: <\/strong> 10.1016\/j.ejmech.2020.112090<\/a><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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11. Optical control of muscular nicotinic channels with azocuroniums, photoswitchable azobenzenes bearing two N-methyl-N-carbocyclic quaternary ammonium groups. Eur. J. Med. Chem<\/em>. May 2020<\/strong>.\u00a0DOI: <\/strong>10.1016\/j.ejmech.2020.112403<\/a><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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12. Aza-CGP37157-lipoic hybrids designed as novel Nrf2-inducers and antioxidants exert neuroprotection against oxidative stress and show neuroinflammation inhibitory properties.\u00a0Drug Development Research.\u00a0<\/em>May\u00a02020<\/strong>.\u00a0DOI:<\/strong>\u00a010.1002\/ddr.21618<\/a><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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13. NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases. Biomolecules<\/em>. Jun 2020<\/strong>. DOI: <\/strong>10.3390\/biom10060904<\/a><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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14. Aging and Progression of Beta-Amyloid Pathology in Alzheimer\u2019s Disease Correlates with Microglial Heme-Oxygenase-1 Overexpression. Antioxidants<\/em>. Jul 2020<\/strong>. DOI<\/strong>: 10.3390\/antiox9070644<\/a><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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15. When It Comes to an End: Oxidative Stress Crosstalk with Protein Aggregation and Neuroinflammation Induce Neurodegeneration. Antioxidants<\/em>. Aug 2020<\/strong>. DOI: <\/strong>10.3390\/antiox9080740<\/a><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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16. Perspectives on the Clinical Development of NRF2-Targeting Drugs. Handbook of Experimental Pharmacology (Chapter).\u00a0<\/em>Aug 2020<\/strong>. DOI:<\/strong> 10.1007\/164_2020_381<\/a><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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17. Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism. Redox Biology. <\/em>Nov 2020<\/strong>. DOI: <\/strong>10.1016\/j.redox.2020.101789<\/a><\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Publications 1. Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy. Redox Biol. Apr 2018.\u00a0DOI: 10.1016\/j.redox.2017.10.010. 2. Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach. Pharmacol Rev. April 2018.\u00a0DOI:\u00a010.1124\/pr.117.014753 3. Transcription factor NFE2L2\/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A. Autophagy. Jul\u00a02018. DOI: … Read more Publications<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"acf":[],"_links":{"self":[{"href":"https:\/\/dev.jatstudio.com\/en\/wp-json\/wp\/v2\/pages\/808"}],"collection":[{"href":"https:\/\/dev.jatstudio.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/dev.jatstudio.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/dev.jatstudio.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dev.jatstudio.com\/en\/wp-json\/wp\/v2\/comments?post=808"}],"version-history":[{"count":8,"href":"https:\/\/dev.jatstudio.com\/en\/wp-json\/wp\/v2\/pages\/808\/revisions"}],"predecessor-version":[{"id":1445,"href":"https:\/\/dev.jatstudio.com\/en\/wp-json\/wp\/v2\/pages\/808\/revisions\/1445"}],"wp:attachment":[{"href":"https:\/\/dev.jatstudio.com\/en\/wp-json\/wp\/v2\/media?parent=808"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}