{"id":488,"date":"2018-12-13T10:37:19","date_gmt":"2018-12-13T10:37:19","guid":{"rendered":"http:\/\/dev.jatstudio.com\/?page_id=488"},"modified":"2022-03-30T08:04:54","modified_gmt":"2022-03-30T08:04:54","slug":"gt1","status":"publish","type":"page","link":"https:\/\/dev.jatstudio.com\/en\/gt1","title":{"rendered":"GT1"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"488\" class=\"elementor elementor-488 elementor-65\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5a7628ad elementor-section-full_width elementor-section-height-min-height elementor-section-items-stretch elementor-section-height-default\" data-id=\"5a7628ad\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-38062489\" data-id=\"38062489\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-77d19c6d elementor-widget elementor-widget-heading\" data-id=\"77d19c6d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">NeuroProtectionLab<br><b> GT1 Coordinator<\/b><\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2f8a6152 elementor-widget elementor-widget-text-editor\" data-id=\"2f8a6152\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<b>NeuroProtectionLab <\/b><span style=\"font-weight: 400;\">is a multidisciplinary and highly motivated research group which members belong to different areas such as pharmacology, medicinal chemistry, biotechnology, bioinformatics, biochemistry, and medicine with the common purpose of <\/span><b>finding innovative therapies for neurodegenerative diseases<\/b><span style=\"font-weight: 400;\"> (NDDs), <\/span><b>with special interest in Alzheimer&#8217;s disease, tauopathies and cerebrovascular diseases.<\/b><span style=\"font-weight: 400;\"> To do this, we develop projects that range from medical chemistry (design and synthesis of molecular models) to the testing of models in animals, including the repositioning of drugs and the fine-tuning of new in vivo neurodegeneration drugs. Our projects focus on the following lines of research:<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a5c7d3d elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"a5c7d3d\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-dot-circle\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Pathophysiological mechanisms of NDDs: identification of targets<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-dot-circle\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Search and identification of new therapies for NDDs<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-fa77154\" data-id=\"fa77154\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c44a5a6 elementor-widget elementor-widget-image\" data-id=\"c44a5a6\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img width=\"824\" height=\"824\" src=\"https:\/\/dev.jatstudio.com\/wp-content\/uploads\/2022\/02\/N2-1-3-DMF10_z0.jpg\" class=\"attachment-full size-full wp-image-2878\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/dev.jatstudio.com\/wp-content\/uploads\/2022\/02\/N2-1-3-DMF10_z0.jpg 824w, https:\/\/dev.jatstudio.com\/wp-content\/uploads\/2022\/02\/N2-1-3-DMF10_z0-300x300.jpg 300w, https:\/\/dev.jatstudio.com\/wp-content\/uploads\/2022\/02\/N2-1-3-DMF10_z0-150x150.jpg 150w, https:\/\/dev.jatstudio.com\/wp-content\/uploads\/2022\/02\/N2-1-3-DMF10_z0-768x768.jpg 768w\" sizes=\"(max-width: 824px) 100vw, 824px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fdb377e elementor-widget elementor-widget-text-editor\" data-id=\"fdb377e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tPrimary culture of neurons from the mouse prefrontal cortex expressing the human tau protein with the P301L mutation.\r\nBlue: nuclei. Red: hyperphosphorylated tau at Ser202\/Thr305. Green: hyperphosphorylated tau at Tyr18.\r\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e17603d elementor-section-full_width elementor-section-height-min-height elementor-section-items-stretch elementor-reverse-mobile elementor-section-height-default\" data-id=\"e17603d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9403473\" data-id=\"9403473\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-85f4d83 elementor-widget elementor-widget-text-editor\" data-id=\"85f4d83\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<span style=\"font-weight: 400;\">NDDs share common <\/span><b>pathophysiological mechanisms<\/b><span style=\"font-weight: 400;\"> such as aging, proteinopathy, oxidative stress, neuroinflammation, mitochondrial dysfunction, or intracellular calcium dyshomeostasis. At this point we are working at several levels:<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d902f6c elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"d902f6c\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-dot-circle\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\"><b>Aging:<\/b>many of our projects are carried out in parallel in adult animals and in aged animals. This allows us to determine the impact of aging on the processes we are studying.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-dot-circle\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\"><b>Neuroinflammation-central immune response:<\/b> we are interested in knowing what is the participation of the cells from the immune system in the central nervous system -the microglia- in the pathophysiology of NDDs since the immune system, with aging, becomes less competent. Likewise, we want to know what the communication signals are between \"the microglia-the astrocyte-the neuron\" to identify targets susceptible to pharmacological modulation that allow neurodegenerative processes to be stopped.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-dot-circle\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\"><b>Oxidative Stress:<\/b> free radicals are signaling molecules necessary for proper cell function, but their excess production can be harmful.  <b>NeuroProtectionLab<\/b> is interested in knowing the participation of NOXs, HO-1 or the master regulator of the antioxidant response - the transcription factor NRF2 - in neurodegenerative processes in order to find drugs that modulate these activities.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d4b834e elementor-widget elementor-widget-text-editor\" data-id=\"d4b834e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<span style=\"font-weight: 400;\">For the search and identification of new therapies for NDDs, we are working in areas such as:<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ffe1f66 elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"ffe1f66\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-dot-circle\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\"><b>Chemical-Medical:<\/b>specifically in the design, synthesis and biological evaluation of multitarget ligands (Multitarget Ligand Drugs- MTLDs), molecules that integrate two or more activities for targets involved in neurodegeneration. Specifically, we are interested in combinations of the following activities: induction of the transcription factor NRF2, inhibition of several enzymes related to neurological disorders (ACE, MAO-B, GSK-3\u03b2), modulators of nicotinic acetylcholine receptors, modulators of melatonin receptors \u2026<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-dot-circle\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\"><b>In silico screening:<\/b> through these bioinformatic methodologies we seek to reposition drugs or find chemical structures that can be chemically modified with therapeutic potential in NDTs and which is based on our previous target identification studies.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a22dbc9 elementor-section-full_width elementor-section-height-min-height elementor-section-items-stretch elementor-reverse-mobile elementor-section-height-default\" data-id=\"a22dbc9\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-51e06b2\" data-id=\"51e06b2\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bc50309 elementor-widget elementor-widget-image\" data-id=\"bc50309\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img width=\"1024\" height=\"1024\" src=\"https:\/\/dev.jatstudio.com\/wp-content\/uploads\/2022\/03\/gt1.jpg\" class=\"attachment-large size-large wp-image-3015\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/dev.jatstudio.com\/wp-content\/uploads\/2022\/03\/gt1.jpg 1024w, https:\/\/dev.jatstudio.com\/wp-content\/uploads\/2022\/03\/gt1-300x300.jpg 300w, https:\/\/dev.jatstudio.com\/wp-content\/uploads\/2022\/03\/gt1-150x150.jpg 150w, https:\/\/dev.jatstudio.com\/wp-content\/uploads\/2022\/03\/gt1-768x768.jpg 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1725d44 elementor-widget elementor-widget-text-editor\" data-id=\"1725d44\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tImage of mouse hippocampus injected with an adeno-associated particle expressing human tau protein with the P301L mutation.\r\nBlue: nuclei. Red: hyperphosphorylated tau at Ser202\/Thr305. Green: hyperphosphorylated tau at Tyr18.\r\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-18c359e\" data-id=\"18c359e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7fcf897 elementor-widget elementor-widget-text-editor\" data-id=\"7fcf897\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<span style=\"font-weight: 400;\">The <\/span><b>NeuroProtectionLab<\/b><span style=\"font-weight: 400;\"> group -directed by Dr. Manuela Garc\u00eda L\u00f3pez, Professor of Pharmacology at the Department of Pharmacology and Therapeutics- is part of:<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-636d153 elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"636d153\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-dot-circle\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">\u201cTe\u00f3filo Hernando\u201d Institute for Medicine R&D (IFTH) of the Universidad Aut\u00f3noma de Madrid (UAM).<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-dot-circle\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">She is principal investigator of the<a href=\"https:\/\/www.iis-princesa.org\/investigacion\/area-2\/linea-2-grupo-16\/\">\"Pharmacological Neuroprotection in Neurodegenerative Diseases and Stroke\" Group (Group 16) <\/a> at the Hospital de La Princesa Research Institute (IIS La Princesa).<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-dot-circle\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Participates in the aging hub of the European alliance <a href=\"https:\/\/civis.eu\/es\">CIVIS European Civic University<\/a>.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>NeuroProtectionLab GT1 Coordinator NeuroProtectionLab is a multidisciplinary and highly motivated research group which members belong to different areas such as pharmacology, medicinal chemistry, biotechnology, bioinformatics, biochemistry, and medicine with the common purpose of finding innovative therapies for neurodegenerative diseases (NDDs), with special interest in Alzheimer&#8217;s disease, tauopathies and cerebrovascular diseases. To do this, we develop &#8230; <a title=\"GT1\" class=\"read-more\" href=\"https:\/\/dev.jatstudio.com\/en\/gt1\">Read more <span class=\"screen-reader-text\">GT1<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"acf":[],"_links":{"self":[{"href":"https:\/\/dev.jatstudio.com\/en\/wp-json\/wp\/v2\/pages\/488"}],"collection":[{"href":"https:\/\/dev.jatstudio.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/dev.jatstudio.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/dev.jatstudio.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dev.jatstudio.com\/en\/wp-json\/wp\/v2\/comments?post=488"}],"version-history":[{"count":58,"href":"https:\/\/dev.jatstudio.com\/en\/wp-json\/wp\/v2\/pages\/488\/revisions"}],"predecessor-version":[{"id":3123,"href":"https:\/\/dev.jatstudio.com\/en\/wp-json\/wp\/v2\/pages\/488\/revisions\/3123"}],"wp:attachment":[{"href":"https:\/\/dev.jatstudio.com\/en\/wp-json\/wp\/v2\/media?parent=488"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}